Sensitivity, Specificity, and Persistence of Chromosome Translocations for Radiation Biodosimetry

Chromosome translocations: a biomarker for retrospective biodosimetry.

We discuss here the results from our studies demonstrating that simple translocations detected by chromosome painting can be used to reconstruct radiation doses for workers exposed within the dose limits and for individuals with past exposure. To be useful, a biomarker for exposure and risk assessment should employ an end point that is highly quantitative, stable over time, and relevant to huma...

Induction of premature chromosome condensation (PCC) by calyculin A for biodosimetry

Background: Premature chromosome condensation (PCC) is a method for interphase chromosome analysis in biodosimetry. This study was performed to verify the usefulness of PCC induced by calyculin A in human peripheral blood lymphocytes (pbl) for biological dosimetry and possible construction of dose-response curve. Materials and Methods: Peripheral blood was obtained from a healthy donor and expo...

Sensitivity and specificity of dilation and curettage for diagnosis of abnormal uterine bleeding

Background: Abnormal uterine Bleeding (AUB) is one of the most common gynecological disorders. Dilatation and curettage is a diagnostic procedure in the management of AUB. Definite treatments such as hysterectomy may be applied based on the results of dilatation and curettage. This study was conducted to evaluate the sensitivity and specificity of dilatation and curettage. Materials and method...

Sensitivity and Specificity of Nucleic Acid Sequence-Based Amplification Method for Diagnosis of Cutaneous Leishmaniasis

Abstract Background and Objective: Culture, microscopic method is a gold standard method for identification of Lishmania parasite. The use of Molecular methods such as RT- PCR compared to microscopic methods has a higher sensitivity and specificity however, it is not widely used due to its expensive equipment and the time requested. The use of nucleic acid sequence based amplification (NASBA) ...

Serum microRNAs – potent biomarkers for radiation biodosimetry